What Is VDR?

VDR is a gene which encodes for a protein which functions as a receptor for vitamin D that regulates bone formation and calcium absorption. A variant of the gene, rs2228570 (FokI polymorphism), is associated with decreased bone mineral density in white prepubertal girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern and temporal on-and-off occupancy of the VDRE between the two components. It is also controlled by chromosomal position and binding preferences for specific hormones. Microarray studies on https://www.gescheftmarketing.de/2021/12/20/what-are-the-risks-in-using-a-file-sharing-system-vs-a-data-room-service/ human cells show that more than 100 genes are enriched with VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) is a repository of information and documents relevant to legal, business transactions, or processes. Viewing, downloading, or printing is restricted. It makes use of central computers and an extranet which is a restricted-access Internet connection, allowing users to login at set times.

VDRs are primarily used by investment banks and companies involved in mergers or acquisitions. They need to be able to share information in a transparent manner with potential investors and buyers. Due diligence procedures will also require a significant amount of data. Life science companies also make use of VDRs for everything from clinical trial data to HIPAA documentation for compliance.